Zitrocin

  • Jun 21, 2018

Zitrotsin analogs:

Zitrocin instructions:

( Azithromycin)

Manufacturer of Zitrocin:

Unic Pharmaceutical Laboratories( branch of JB Chemicals and Pharmaceuticals Ltd.), India.

Active substance Zitrocin:

5 ml of the prepared suspension contain: azithromycin dihydrate is equivalent to azithromycin anhydrous - 200 mg.

1 tablet contains azithromycin dihydrate equivalent to azithromycin anhydrous - 250, 500 mg.

Zitrocin release form:

Powder for preparation of 30 ml( 200 mg / 5 ml) of oral suspension in vials No.1.Tablets coated with 250 mg of No. 6.

Tablets coated with 500 mg of No. 3.

To whom Sitrocin is indicated:

Infectious inflammatory diseases caused by drug-susceptible microorganisms:

  • respiratory tract infec
    tions and ENT organs( pneumonia, bronchitis, whooping cough, tonsillitis, sinusitis, tonsillitis, otitis media, scarlet fever);
  • infections of the skin and soft tissues( erysipelas, impetigo, secondarily infected dermatoses);
  • infections of the urogenital tract( gonorrheal and non-renal urethritis, cervicitis, chlamydia, prostatitis, salpingitis);
  • oral infection( periodontitis, periostitis)
  • Lyme disease( borreliosis), for treatment of the initial stage( erythema migrans );
  • peptic ulcer of the stomach and duodenum, associated with Helicobacter pylori ( as part of complex therapy).

How to use Sitrocin:

Powder for the preparation of oral suspension

Zitrocin in suspension is recommended mainly to children, but can also be used by adults( if Zitrocin is not available in the form of tablets).

Children with a body weight of 10 to 45 kg: for upper and lower respiratory tract infections, skin and soft tissue Zitrocin is recommended at a dose of 10 mg / kg body weight for 3 days.

For chronic migratory erythema( Lyme disease), the drug is used once a day for 5 days: on the first day, a dose of 20 mg / kg of body weight, the next 4 days - 10 mg per 1 kg of body weight.

For children with a body weight of more than 45 kg, the drug is prescribed in the same doses as for adults. For infections of the respiratory tract, skin and soft tissue - 500 mg for 3 days( course dose - 1.5 g) or 500 mg of the first day, and then - 250 mg per day from 2 to 5day of treatment).

For chronic migratory erythema( Lyme disease), the drug is used once a day for 5 days: on the first day the dose is 1g, the next 4 days - 500 mg.

When infections of the urogenital tract are prescribed in a dose of 1 g once.

For complex therapy of peptic ulcer of stomach and duodenum caused by Helicobacter pylori , the drug is prescribed at a dose of 1 g / day for 3 days.

If you miss a dose of 1 dose, the missed dose should be taken as soon as possible, and the subsequent dose - with interruptions of 24 hours.

Suspension Zitrocin should be taken 1 hour before meals or 2 hours after meals, the frequency of intake is 1 time per day.

Pharmacokinetic properties allow the use of Zitrocin in short courses from 3 to 5 days, there is no need to prolong the intake of the drug.

Tablets

Zitrocin should be taken 1 hour before meals or 2 hours after meals apply once a day.

Adults and children with body weight over 45 kg

- For infections of the respiratory tract, skin and soft tissues, the oral cavity is prescribed 500 mg for 3 days( course dose 1.5 g) or 500 mg 1 day, then250 mg from the 2nd to the 5th day of treatment. The course dose is 1.5 g;

- With Lyme disease( borreliosis) -1 g of the first day and 500 mg daily from day 2 to day 5( course dose - 3 g).

- In peptic ulcer of stomach and duodenum associated with Helicobacter pylori, the drug is prescribed at a dose of 1 g for 3 days( as part of a combination therapy).

- In acute infections of the urogenital organs( gonorrhea and non-gonorrheal urethritis, cervicitis, chlamydia, prostatitis, salpingitis) - adults receive 1 g of the drug once.

Children with a body weight of 10 kg to 45 kg Zitrocin is recommended as a suspension.

If you miss a dose of 1 dose, the missed dose should be taken as soon as possible, and the subsequent dose should be taken at 24-hour intervals.

Caution is advised to prescribe Zitrocin to a patient with severe impairment of liver and kidney function. Also, use caution when appointing patients with arrhythmias( possibly prolonging the QT interval).

The administration of Zitrocin during pregnancy is only possible if the benefit to the mother exceeds the possible risk to the fetus. When lactation during treatment, stop breastfeeding.

There is no need to change the dose for the elderly and take the drug longer than recommended.

Drug administration does not affect the ability to drive vehicles and mechanisms.

Side effects of Zitrocin:

Total drug is characterized by a low incidence of side effects. Most of them were observed from the gastrointestinal tract: nausea, anorexia, flatulence, diarrhea. From time to time, reversible transient increases in hepatic transaminase activity occurred.

Allergic reactions may occur, such as skin rash, hives, eosinophilia, neutrophilia / neutropenia. Modified indicators usually normalize 2-3 weeks after the end of treatment.

To whom is contraindicated Zitrocin:

Powder for the preparation of oral suspension

Hypersensitivity to the components of the preparation. Do not appoint children with a body weight of 10 kg.

Tablets

Hypersensitivity to the components of the drug. The drug in this dosage form is not recommended for children with a body weight of 45 kg.

Interaction of Zitrocin:

Between the intake of Zitrocin and antacid preparations, a minimum of 2-hour break is recommended.

Unlike most macrolide antibiotics, azithromycin does not bind to the enzymes of the cytochrome P450 complex, therefore it practically does not interact with digoxin, ergotamine, cyclosporine, carbamazepine, theophylline and other xanthine derivatives, phenytoin, triazolam or oral anticoagulants. Tetracyclines and chloramphenicol increase the effect of azithromycin, and the lincosamides are reduced.

Zitrocin overdose:

Symptoms: temporary loss of hearing, weakness, severe nausea, vomiting and diarrhea.

Treatment: gastric lavage - if necessary, administration of activated carbon, restoration of water-electrolyte balance, elimination of gastrointestinal tract irritation, hemosorption.