Nalgezin( Naproxen) analogues:
Nalgezin( Naproxen) Instruction:
KRKA d.d., Slovenia
The active substance of Nalgezin
Nalgezin Release Forms
Film-coated tablets at 275 mg, 550 mg No. 10
To which Nalgezin is indicated
Nalgezine is used for:
- headache and toothache;
- treatment and prevention of migraine;
- pain in the muscles, joints and spine;
- menstrual pain;
- pain in muscles and joints for colds and flu
- post-operative pain.
How to use Nalgezin
Method of administration and dose.
Adults, elderly people, are given 1 tablet every 8-12 hours( maximum daily dose of 3 tablets) during the period when symptoms occur. At the beginning of treatment, a double dose, or two tablets together, or a second tablet one hour after the first is prescribed. Duration of treatment should not exceed 3 days without consulting a doctor! Take the tablets with a glass of water.
Warnings and Cautions
Patients should notify their physician of any chronic illness, metabolic disorder, or history of hypersensitivity reactions.
Patients with upper gastrointestinal disease in a history should be under medical supervision during treatment.
Care should be taken to prescribe naproxen to patients with ulcerative colitis and Crohn's disease because of the possibility of recurrence or exacerbation of the disease.
Caution should also be exercised when prescribing to patients with severe impairment of renal and hepatic function, heart failure, patients with epilepsy, porphyria, hemostasis disorders and also patients treated with anticoagulants or fibrinolytics.
One tablet of nalgezin contains 25 mg of sodium. This should be borne in mind if the patient is on a salt-free diet.
Pregnancy and lactation.
The drug can be given to pregnant women only in cases where the need of the mother exceeds the possible risk to the fetus.
Naproxen is not recommended for use during the last trimester of pregnancy and during lactation.
Effect on the ability to drive and use other vehicles.
There are no reports that these drugs can affect the ability to drive a car or other technical means.
Side effects of Nalgezin
Side effects are most often associated with taking large doses of the drug.
The incidence of adverse events from 3% to 9%: gastrointestinal disorders( abdominal pain, nausea, dyspepsia, diarrhea), dizziness, fatigue, sleep disturbance, noise, in the ears, edema of the feet.
Very rarely there are such side effects( frequency & lt; 1%) as gastrointestinal bleeding, face swelling, urticaria, asthmatic attack or fainting.
Contraindicated to Nalgezin
The drug should not be taken to patients: hypersensitivity to naproxen or to any of the ingredients of the drug, as well as to other non-steroidal anti-inflammatory drugs, with a stomach ulcer or duodenal ulcer, gastrointestinal bleeding.
Nalgesine should not be used in children under 14 years of age.
Interaction of Nalgezin
- The simultaneous use of naproxen with acetylsalicylic acid or other non-steroidal anti-inflammatory drugs - increases the risk of unwanted effects, with lithium - increases the concentration of the latter in plasma;
- with diuretics - can reduce diuretic effect;
- application together with cyclosporine may enhance the nephrotoxicity of cyclosporine;
- with methotrexate - may increase the toxicity of methotrexate;
- with antihypertensive drugs - reduces the effectiveness of these drugs.
It should be borne in mind that if applied simultaneously with anticoagulants, naproxen may increase bleeding time.
Overdose of Nalgezin
Taking an excess of the drug may cause nausea, vomiting, epigastric pain, dizziness, ringing in the ears and arousal, sometimes vomiting with blood, melena, impaired consciousness, respiratory depression, seizures, acute kidney failure.
If such symptoms are observed, it is necessary to rinse the stomach and prescribe activated charcoal. If necessary, it is possible to administer an antacid, H2 histone receptor blockers, proton pump inhibitors or misaprostol, and symptomatic treatment should be performed.