Eufillin-Darnitsa( theophylline) analogues:
Euphyllin-Darnitsa( Theophylline) Instruction:
Active ingredients Eufillina-Darnitsa:
Solution for injection 2% 5 ml or10 ml in ampoules No. 10;10 ml in ampoules No. 5.
To whom is the Euphyllin-Darnitsa shown?
Bronchoobstructive syndrome: chronic obstructive bronchitis in the acute stage, bronchial asthma( a drug of choice in patients with asthma of physical stress and as an adjunct in other forms of asthma), asthmatic status( complementary therapy), emphysema, chronic obstructive pulmonary disease in the acute stage, apneainfants. Violation of cerebral circulation by ischemic type( as part of combination therapy).Left ventricular failure with bronchospasm and respiratory depression by type of Cheyne-Stokes, pulmonary hypertension, pulmonary heart, edematous syndrome of renal genesis( as part of complex therapy).
How to use Euphyllin-Darnitsa?
The drug is administered intravenously slowly. The dose of the drug is selected individually, given the possibility of different rates of excretion in different patients.
Adults prescribe at 10 mg / kg, on average, from 600-800 mg per day, distributed on the 1-3th of January. For patients with low body weight, the dose of the drug is reduced to 400-500 mg / day, with the first administration not more than 200-250 mg.
For children aged 6-17 years, the drug is prescribed in a dose of 13 mg / kg of body weight, children under 6 years of age - 16 mg / kg of body weight per day in 1-3 injections.
The drug is administered under the control of blood pressure, heart rate, respiratory rate and general condition of the patient. The duration of treatment depends on the severity and course of the disease, the sensitivity to the drug and can range from a few days to two weeks.
Use in pregnancy and lactation is possible only for vital indications. With special care, a drug should be used to treat patients with myocardial infarction in the acute phase.
Before administration, the solution must be heated to body temperature.
The effects of the drug can be greatly enhanced by the simultaneous use of foods high in caffeine or theobromine( coffee, tea, chocolate, etc.).Side effects of Euphyllin-Darnitsa.
- From the nervous system: agitation, anxiety, insomnia, headache, tremor, irritability.
- Cardio-vascular system: heartbeat, arrhythmia, tachycardia, extrasystole, lowering of arterial pressure, heart failure, increased frequency of angina attacks, collapse( with rapid intravenous injection).
- From the side of the urinary system: an increase in diuresis.
- In pregnant women: the fetus manifests tachycardia( when applied in the last trimester).
- Allergic reactions: skin rash, itching of the skin.
- Local reactions: reactions at the injection site( compaction, flushing, soreness).
Side effects decrease with a decrease in the dose of the drug.
Who is contraindicated with Euphyllin-Darnitsa?
Hypersensitivity to the drug components( including other xanthine derivatives: caffeine, pentoxifylline, theobromine).Pulmonary edema. Severe arterial hyper- and hypotension, widespread atherosclerosis of blood vessels, hemorrhagic stroke, hemorrhage in the retina, decompensated chronic heart failure, tachyarrhythmia. Increased convulsive readiness, epilepsy. Severe hepatic and / or renal insufficiency. Uncontrolled hypothyroidism. Sepsis. Peptic ulcer of the stomach and duodenum( in the stage of exacerbation), gastroesophageal reflux, bleeding in a recent history.
Interaction of Euphyllin-Darnitsa.
Do not use together with other xanthine derivatives. Strengthens the effect of sympathomimetics and diuretics( due to increased glomerular filtration), reduces the effectiveness of lithium and α-adrenoreceptor drugs. In combination with phenobarbital, phenytoin, rifampicin, isoniazid, carbamazepine, sulfinpyrazone, aminoglutethimide and moracizine, a decrease in the efficacy of euphyllin is observed, which may require an increase in its dose. When used together with antibiotics, a group of macrolides, lincomycin, allopurinol, cimetidine, isoprenaline, propranolol, oral contraceptives, enoxacin, ethanol, disulfiram, fluoroquinolones, interferon-α recombinant, methotrexate, mexiletine, propafenone, tiabendazole, ticlopidine, verapamil and vaccine against influenzathe intensity of action may increase, which will require a reduction in the dose of euphyllin. Caution is prescribed concomitantly with anticoagulants.
Overdose of Euphyllin-Darnitsa.
Symptoms: anorexia, nausea, vomiting, headache, dizziness, irritation, irritability. Sometimes the first manifestations may be convulsions, ventricular arrhythmia. In severe poisoning, especially in children, epileptic seizures may occur without the appearance of any precursors.
Treatment. Termination of drug treatment. If seizures occur, maintain airway patency and give oxygen. To stop the attack, do intravenous diazepam in doses of 0.1-0.3 mg / kg( but not more than 10 mg).With severe nausea and vomiting, make an intravenous injection of metoclopramide or ondansetron. If necessary, hemoperfusion, hemodialysis is less effective.