Nimulide( nimesulide)

  • Jul 04, 2018

nimulid( nimesulide) analogues:

Nimulide( nimesulide) Instruction:


Active substance Nimulide

Forms of Nimulide release

  • Tablets 100 mg No. 30 No. 100
  • Transdermal gel 1% to 30 g in tubes
  • Solution for injection, 75 mg / 2 ml 2 ml eachampoules № 5
  • Suspensionfor oral administration( 50 mg / 5 ml) of 30 ml, 60 ml in bottles № 1
  • Tablets for sucking for children 50 mg, for adults 100 mg No. 10 № 100( 10х10)

To whom is Nimulide

Ostearthritis, rheumatoidarthritis, bursitis, tendonitis, gout, musculoskeletal and soft tissue injuries, sports injuries, pain syndrome of different genesis, primary dysmenorrhea, and infectious inflammatory disease.

How to use Nimulide

Method of administration and dose.


Adults and children over 12 years of age: The usual oral dose is 100 mg( 1 tablet) 2 times a day. Depending on the severity of the condition and the effectiveness of therapy, the dose of the drug can be increased to 3 tablets per day. Duration of treatment - from several days in most cases to several months with osteoarthritis.

Tablets are taken with a sufficient amount of water, preferably before taking food. If irritation is observed on the stomach, Nimulide is taken after or during meals.

Transdermal gel

For external application, the surface of the skin should be washed and dried before applying the gel. A strip of gel about 3 cm long is applied to the painful parts of the body with a thin layer and slightly rubbed, the frequency of application is 3 to 4 times a day.

Nimulide therapy can vary depending on the site of the lesion and the response to treatment. The duration of the course of therapy is determined individually depending on the effectiveness of therapy and is no more than 4 weeks.

Solution for injection

1 ampoule - 2 ml of the drug( 75 mg) twice a day by subcutaneous injection.

The duration of treatment is determined individually before the therapeutic effect is achieved.

Suspension for oral administration

For dysmenorrhea - 5-10 ml twice daily.

In severe pain syndrome - 20 ml twice a day.

Children from 6 years of age, the suspension is prescribed at the rate of 5 mg / kg of the child's body weight according to this scheme.

Weight( kg) Daily dose
6 - 8 2 ml - twice daily
9 - 12 2 ml - three times daily
13-16 4 ml twice daily
17 - 20 5 ml -twice a day
21 - 24 4 ml - thrice a day

Children over 6 years of age are prescribed 5-10 ml of suspension twice a day.

The duration of treatment is 7-10 days.

Suspension is taken before meals. If dyspeptic phenomena are observed, Nimulide is taken after a meal, squeezed with enough liquid.

Tablets for sucking for children

Children from 6 to 12 years are prescribed 1-2 tablets( 50-100 mg) twice a day.

Duration of use is 7-10 days. Tablets are taken before meals. If dyspeptic phenomena are noted, Nimulide is taken after a meal.

Application features.

Like other non-steroidal anti-inflammatory drugs, Nimulide should be administered with caution to patients with impaired liver function, cirrhosis, congestive heart failure, kidney disease, or patients with impaired salt metabolism.

When taking non-steroidal anti-inflammatory drugs, including Nimulide, it is recommended to periodically determine the levels of functional hepatic tests in serum. In the event of worsening of these liver tests, the drug is immediately withdrawn.

Pregnancy and lactation.

Nimulide should not be used during pregnancy and during lactation.

Influence on ability to drive vehicles and mechanisms.

Due to the fact that Nimulide may internally lead to dizziness and drowsiness, the drug should be administered with caution to patients who engage in potentially hazardous activities that require increased concentration of attention and rapid psychomotor reactions.

Side Effects of Nimulide

  • Pain in epigastrium, heartburn, nausea, diarrhea, vomiting.
  • Skin reactions in the form of rashes and itching are possible.
  • From the side of the nervous system, headache, dizziness, drowsiness, sleep disturbance, increased sweating and excitability are possible.
  • Sometimes there are increases in the activity of liver enzymes.

Who is contraindicated Nimulide

  • Peptic ulcer of the stomach and duodenum, expressed by hepatic and renal failure;
  • acute bleeding in the gastrointestinal tract;
  • increased sensitivity to nimesulide and other non-steroidal anti-inflammatory drugs;
  • pregnancy and lactation periods.
  • Children under 12 years.

Nimulide interaction

Since Nimulide binds intensely to plasma proteins, it can be displaced from binding sites while being used with phenobarbital, salicylic acid, valproic acid, tolbutamide.

Moreover, Nimulide can displace salicylic acid, methotrexate and furosemide from binding sites.

Nimulide reduces the diuretic effect of furosemide and warfarin, which are applied together.

In clinical practice, interaction with oral coagulants or other drugs that bind firmly to proteins can not be ruled out. Nimulide can induce the induction of the theophylline enzyme with simultaneous application.

Nimulide, when taken on an empty stomach, does not significantly affect the tolerability of glucose in patients who take drugs to treat diabetes.

Increases the level of lithium in plasma.

Overdose of Nimulide

When an overdose occurs, symptoms that are characteristic of the side effect of the drug on the body. Treatment: gastric lavage, prescription of activated charcoal;if necessary, perform symptomatic treatment.