Siofor( metformin) analogues:
Siofor( metformin) instruction:
BERLIN-CHEMIE AG( MENARINI GROUP), Germany
Form release Siofor
Tablets coated with 1000 mg No. 30( 15x2), No. 60( 15x4), No. 120( 15x8)
Tablets coated with 500 mg No. 30( 10x3),No. 60( 10x6), No. 120( 10x12)
Tablets coated with a coat of 850 mg No. 30( 15x2), No. 60( 15x4),No. 120( 15x8)
To whom is Siofor shown?
Diabetes mellitus type II, especially in patients with overweight, in which only one diet and exercise, the adjustment of blood sugar levels is not achieved enough.
How to use Siofor?
The drug is taken during or after meals twice or thrice a day. The initial dose is 500 mg per day( ½ tablet coated with Siofor).After 10-15 days the dose should be adjusted according to the indicators of blood sugar level. The sequence of increasing dosage favorably affects the sensitivity to the preparation of the digestive tract. The maximum daily dose is 3 g of Siofor. To achieve a better correction of blood sugar, metformin can be combined with insulin. It is prescribed in usual doses( 500 mg - 850 mg 2-3 times a day), while the dose of insulin depends on the measured blood sugar.
Due to the lack of experience in the use of Siofor in children is not recommended. Before and during the treatment with metformin, kidney function should be monitored, namely: at least once a year in patients with normal renal function;2-4 times a year in patients with a level of creatinine, which is near the upper limit of the norm, as well as in elderly people. Particular caution is required in situations where there may be a restriction of renal function( eg, initiation of treatment with antihypertensive drugs, diuretics or non-steroidal anti-inflammatory drugs).Since intravascular administration of contrast agents in radiological studies may lead to renal failure, metformin should be discontinued before, during, and within 48 hours of the study. Continue therapy is possible only if a fresh study determines the normal function of the kidneys.48 hours before the planned surgical intervention, which will be performed under anesthesia, you should stop taking metformin. Continue treatment is recommended no earlier than 48 hours after surgery.
During treatment with metformin, the following is recommended: all patients continue to adhere to the diet, and patients with excess weight continue to adhere to a low-calorie diet;Conduct regular laboratory examinations, which are recommended for patients with diabetes mellitus;Metformin itself does not lead to hypoglycemia, but when combined with insulin or sulfonylurea preparations, one must be careful. Monotherapy with metformin does not lead to hypoglycemia and therefore does not affect the ability to drive vehicles and manage mechanisms. But we must inform the patient that when metformin is combined with other antidiabetics( sulfonylureas, insulin, repaglinide), there is a risk of developing hypoglycemia. It is necessary to avoid the use of alcohol and drugs containing alcohol.
Side Effects Sioforum
Digestive tract. Very often( & gt; 10%) there are complaints of nausea, vomiting, diarrhea, abdominal pain and loss of appetite. They appear most often at the beginning of treatment and in most cases are spontaneous. Often( 1-10%) there are complaints of metallic taste in the mouth.
Leather. Very rarely( & lt; 0.01%) in patients with hypersensitivity appears mild erythema.
Disorders from the metabolism. Very rarely( & lt; 0.01%) there is a decrease in absorption of vitamin B12, as well as with prolonged treatment, a decrease in its serum concentration. Clinically, this observation probably does not matter.
Lactate Acidosis. Very rarely( 0.03 cases per 1000 patients per year).
Who is contraindicated in Siofor?
Hypersensitivity to metformin or other components of the drug;Diabetic ketoacidosis;Diabetic precoma;Renal failure or impaired renal function( eg, serum creatinine> 135 μmol / L in men and> 110 μmol / L in women);Acute conditions that can lead to impaired renal function( eg, dehydration, severe infection, shock);Intravascular injection of contrast agents containing iodine;Acute and chronic diseases that can lead to hypoxia( eg, cardiac or respiratory failure, acute myocardial infarction, shock);liver failure;Acute alcohol intoxication;alcoholism;Pregnancy and the period of breastfeeding.
At a dose of up to 85 g metformin, hypoglycemia did not develop, even if lactatacidosis developed under the same conditions. With a significant overdose and the presence of concomitant risk factors, lactic acidosis may develop. In this case, it is an emergency clinical case, which requires inpatient treatment. The most effective method of removing lactate immetformin is hemodialysis.
Combinations that are not recommended. Alcohol. In acute alcohol intoxication is an increased risk of lactic acidosis, especially with concomitant fasting, malnutrition or liver failure. Combinations that require extreme caution. Glucocorticoids( systemic and for external use) have increased endogenous hyperglycemic activity. Therefore, more frequent monitoring of blood sugar levels in patients who use such drugs, especially at the beginning of treatment. If necessary, the dose of the antidiabetic remedy is adjusted during such treatment and after its termination. Angiotensin converting enzyme inhibitors can lead to a decrease in blood sugar, which may also require correction of the dose of antidiabetics during and after treatment.