Unipack( yogexol)

  • Jul 04, 2018






Children & lt; 7 kg
Children & gt; 7kg

300 or 350 mg of iodine / ml
240 or 300 mg of iodine / ml
240 or 300 mg of iodine /ml

40-80 ml
4 or 2 ml / kg
3 or 2 ml / kg
( max 40 ml)

Higher doses can be used for high-dose urography

- aortography( arches)
- selective cerebralangiography
- aortography
- fairy
- other types of angiography

300 mg iodine / ml
300 mg iodine / ml
300 mg iodine / ml
300 or 350 mg iodine / ml
300 mg iodine / ml

30 - 40 ml
5 - 10 ml
30 - 60 ml
30 - 50 ml
depending on the type of study

Phlebography( lower extremities)

240 or 300
mg of iodine / ml

20 - 100 ml / limb,

- adults, introduction
to the left ventricle
and aortic root
- selective coronary angiography
- children

350 mg yoyes / ml
350 mg iodine / ml
300 or 350 mg iodine / ml

30 - 60 ml
4 - 8 ml
1-1.5 ml / kg

Depending on the age, weight, pathology( max. 8 ml / kg)

Digital subtraction angiography
- in / arterial
- in the nasal

240,300 mg iodine / ml
300, 350 mg iodine / ml

1 - 15 ml
30 - 60 ml

Total amount of iodine,
as a rule 87 - 88g

Contrast enhancement with CT

240 mg iodine / ml
300 mg iodine / ml
350 mg iodine / ml
240 mg iodine / ml
300 mg ioda / ml

100 - 250 ml,
100 - 200 ml
100 - 150 ml
2-3 ml / kg body weight up to 40 ml
1-3 ml / kg body weight up to 40 ml

The total amount of iodine is generally, 30-60 g
In some cases it is possible to administer up to 100 ml

Enter intrathecally, slowly, for 1-2 minutes

- lumbar and
thoracic( lumbar
- cervical
( lumbar.introduction)
( cervical introduction)
- CT cisternography

240 mg iodine / ml
240 or 300 mg iodine / ml
240 or 300 mg iodine / ml
240 mg iodine / ml

8 - 12 ml
10-12 or7-10 ml
6 -10 or 6 - 8 ml
4 - 12 ml

Lumbar puncture
Lumbar puncture
lateral cervical puncture
Lumbar puncture

Myelography in children
& lt;2 years
2-6 years old
& gt;6 years

240 mg iodine / ml
240 mg iodine / ml
240 mg iodine / ml

1,5 - 4 ml
3 - 6 ml
4 - 8 ml

To minimize the risk of adverse reactions, the total dose of iodine should not exceed 3 g.


- Arthrography
- Gyneography
- Hysterosalpingo
- Sialogram
- Gastrointestinal Tests for Oral Administration
- esophagus
- stomach
Preterm infants
Rectal administration:
- children

240, 300, 350 mg iodine / ml
240 mg iodine / ml
240 mg iodine / ml
240 or 300 mg iodine / ml
240 or 300mg iodine / ml
240, 350 mg iodine / ml
300, 350 mg iodine / ml
diluted with water to a concentration of 100-150 mg iodine / ml
350 mg iodine / ml
diluted with water to a concentration of 100-150 mg iodine / ml

5 to 20, 15,
10 ml respectively
20 - 50 ml
50 ml
15 to 50.25 ml respectively
0.5 - 2 ml
The choice is carried out individually
2-4 ml / kg body weight
4-5 ml /kg body weight
2-4 ml / kg body weight
5-10 ml / kg body weight

The amount of administration depends on the hernia volume
The maximum dose is 50 ml
Example: dilute Unipack 300 and

Gain at CT
Oral administration
- Adults
- Children
Rectal administration

Dilute with water to a concentration of about
6 mg iodine / mL
Dilute with water to a concentration of about
6 mg iodine / mL
Dilute with water to a concentration of about
6 mg iodine / mL

800-2000 mL
solution 15/20 mL solution per kg body weight

Example: dilute Unipack 300 or 350 with water 1:50

Unipack( yogexol) analogues:

Unipack( yogexol) Instruction:


Unique Pharmaceutical Laboratories, India

Active substance Unipack


Forms of Unipack

Solution for injection( 240, 300 or 350 mg / ml) of 20 ml in ampoules No. 5;To 50 ml or 100 ml in bottles No. 1

To whom Unipack is indicated

Unipack is prescribed to children and adults for radiopaque studies:

  • cardioangiography( ventriculography, selective coronary arteriography),
  • aortography( root, aortic, ascending, abdominal aortic arch and itsbranches),
  • angiography of the lungs, head, neck, brain, abdomen, kidney;excretory urography, phlebography, collateral circulation;
  • lumbar, thoracic and cervical myelography,
  • cystography,
  • arthrography,
  • endoscopic retrograde cholangiopancreatography( ERGG),
  • salpingography,
  • sialography and digestive tract research,
  • hernography.
  • Also used to increase the clarity of computed tomography.

How to use Unipack

Method of administration and dose
Unipack is administered intrathecally, intravenously, intraarterially, intraurethrally, transurethally, intraperitoneally, internally.
Myelography - injected intrathecally, slowly, for 1-2 min.

Features of the application of
Diagnostic procedures with Unipack should be performed only in a hospital with an intensive care unit and resuscitation. Before the introduction of Unipack, it is necessary to normalize the patient's electrolyte electrolyte balance. After the administration of the drug, the patient should be under supervision for at least 1 hour. Patients who take neuroleptic drugs should cancel them 2 days before the study.
Before use, the solution should be carefully inspected with regard to the presence of inclusions or discoloration.
Cautiously prescribed for children and elderly patients in connection with the possible development of serious adverse reactions, including aseptic meningitis.
It is necessary to prevent studies using Unipack in patients with epilepsy and with increased seizure readiness.
Caution should be exercised when administering Unipack to patients with renal and hepatic insufficiency, thyrotoxicosis, myeloma, diabetes. It is not recommended to re-introduce the contrast immediately after the procedure, which failed, because in such a situation there is a high risk of overdose. It is advisable to carry out a re-examination after 5-7 days.
Unipack is especially cautiously administered intravenously to patients with paraproteinemic hemoblastoses, due to the high risk of developing irreversible acute renal failure.
When carrying out angiocardiography, patients should be carefully selected for patients with right ventricular failure and pulmonary hypertension.
Angiography for obstruction of the aortoclub segment or femoral artery, increased pressure in the abdominal cavity, hypotension and hypertension requires careful monitoring of the patient during the study due to the risk of neurological complications. In the presence of local and systemic infections with possible bacteremia, a lumpal injection of Unipack is not performed.
It is recommended to prevent the use of the drug during pregnancy and lactation.
The drug may cause allergic reactions( even anaphylactic).If the patient has a history of information on allergic reactions to iodine preparations, it is necessary to premedicate with glucocorticosteroids and antihistamines. Unipack can give incorrect results of thyroid radioisotope investigation within several weeks after administration.
Maximum radiopaque in normal myelography is observed after 30 minutes, after 1 year is not visualized. With CT, contrast in the thoracic region is possible within 1 hour, cervix - 2 hours, basal cisterns - 3-4 hours.
When taken internally promotes the visualization of the digestive tract and is practically not absorbed. Absorption is significantly increased when intestinal perforation or obstruction is present. Contrasting of joint cavities, uterine cavity, pancreatic and bile ducts, bladder is carried out by direct introduction of Unipack.

Side effects of Unipack

Unipack can develop side effects such as fever, pain at the injection site, heart rhythm disturbances, chest pain, hypotension, headache, dizziness, nausea, vomiting, back pain, neck, stiffness, neuralgia, paresthesia, seizures, allergic reactions( even anaphylactic).
In very rare cases development of encephalopathy and aseptic meningitis is not excluded.

To whom is contraindicated Unipack

Contraindications are known earlier reactions of hypersensitivity to iodine preparations, pregnancy, lactation. Relative contraindication is epilepsy.

Unipack interaction

In case of intrathecal injection, Unipack is incompatible with corticosteroids.
Do not inject into any syringe with any other medicines. With simultaneous application of Unipack with neuroleptics, MAO inhibitors, tricyclic antidepressants, analeptics, antipsychotic drugs, the risk of epileptic attacks increases. Antihypertensive drugs increase the risk of developing hypotension during the study. Unipack enhances the toxic effect of other drugs.

Overdose Unipack

When an overdose occurs bradycardia, acidosis, stupor, coma, symptoms of meningism, seizures. In this case, therapy is directed to support vital functions and symptomatic treatment.